Geldanamycin and its derivates - a students review

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<a href="http://www.fermentek.co.il/geldanamycin.htm">Pure geldanamycin is produced by Fermentek in batches 12 kg large</a>


<a href="http://www.fermentek.co.il/geldanamycin.htm">&nbsp;


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J Antibiot (Tokyo). 1989 Apr;42(4):604-10.

12. Inhibition of c-myc gene expression in murine lymphoblastoma cells by geldanamycin and herbimycin, antibiotics of benzoquinoid ansamycin group

  • Yamaki H,
  • Iguchi-Ariga SM,
  • Ariga H.

We have shown that Geldanamycin , an antibiotic of benzoquinoid ansamycin group, inhibits DNA replication in cultured mouse lymphoblastoma L5178Y cells. Here we report that Geldanamycin selectively inhibited the expression of c-myc gene, proto-oncogene, along with suppression of DNA replication in L5178Y cells, which are consistent with our previous results that c-myc protein promotes cellular DNA replication. The significantly enhanced inhibition by Geldanamycin of DNA replication was observed, when the antibiotic was introduced at G1 stage prior to S phase of cell cycle. The results are in favor of the prospects that Geldanamycin inhibits DNA replication mainly at time of initiation, and that c-myc protein is essential for the initiation of cellular DNA replication. Furthermore, when c-myc expression was inhibited by Geldanamycin, the expression of p53 gene, the product of which may be another DNA replication protein, was stimulated in the tumor cells. Thus, Geldanamycin should be useful to investigate the molecular mechanism of DNA replication promoted by c-myc protein and also to distinguish the function of c-myc protein from that of p53 protein in DNA replication.

PMID: 2656616

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

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